OK, I'm on a coast to coast flight, but i'm overwhelmed with messages about the firings. The FDA as we've known it is finished, with most of the leaders with institutional knowledge and a deep understanding of product development and safety no longer employed. I believe that history will see this a huge mistake. I will be glad if I'm proven wrong, but even then there is no good reason to treat people this way. It will be interesting to hear from the new leadership how they plan to put "Humpty Dumpty" back together again.